MyBioSource.com's PDZD3 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The PDZD3 Antibody (Center) was generated using NHERF4 as the antigen and it reacts with Human.
Description
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces
cGMP following the binding of either endogenous ligands or
heat-stable enterotoxins secreted by E. coli and other enteric
bacteria. Activation of GCC initiates a signaling cascade that
leads to phosphorylation of the cystic fibrosis transmembrane
conductance regulator (CFTR; MIM 602421), followed by a net efflux
of ions and water into the intestinal lumen. IKEPP is a regulatory
protein that associates with GCC and regulates the amount of cGMP
produced following receptor stimulation (Scott et al., 2002 [PubMed
11950846])